The smart Trick of indazole pka That No One is Discussing
51 nM. These finding points out the outstanding position of methylene linker incorporated among the terminal phenyl and substituted piperazine in increasing BCR-ABLWT inhibition, which can stem from the power of extended piperazine moiety to form tight interactions Using the allosteric web site of ABL. The NIn summary, An array of three-carboxami